The HBO series has 22 nominations in total, followed by sci-fi series Westworld and comedy show Saturday Night Live, both with 21.
It is the first time in 18 years that HBO did not have the highest number of Emmy nominations.
Netflix leads with a total of 112 nominations, beating HBO, which received 108.
In 2017, The Handmaid's Tale became the first show from a streaming platform to receive the award for best drama.
This year several actresses from the dystopian drama have received nominations, including Elizabeth Moss and Alexis Bledel.
Several British actors have received nominations for the awards also.
Millie Bobby Brown is up for the best supporting actress award for her performance in Netflix's Stranger Things.
Claire Foy, from HBO's royal drama The Crown, is nominated for the best actress award alongside her cast mates Matt Smith and Vanessa Kirby, who were nominated for the best supporting actor and best supporting actress awards.
Benedict Cumberbatch is nominated for Patrick Melrose.
The Late Late Show with James Corden is up for the outstanding variety talk show award.
Best lead actress in a drama series
Sandra Oh - Killing Eve
Keri Russell - The Americans
Tatiana Maslany - Orphan Black
Claire Foy - The Crown
Evan Rachel Wood - Westworld
Elisabeth Moss - The Handmaid's Tale
Best lead actor in a drama series
Jason Bateman - Ozark
Matthew Rhys - The Americans
Milo Ventimiglia - This Is Us
Sterling . Brown - This Is Us
Ed Harris - Westworld
Jeffrey Wright - Westworld
Best lead actress in a limited series or movie
Sarah Paulson - American Horror Story: Cult
Michelle Dockery - Godless
Edie Falco - Law & Order True Crime: The Menendez Murders
Regina King - Seven Seconds
Jessica Biel - The Sinner
Laura Dern - The Tale
Best lead actor in a limited series or movie
Antonio Banderas - Genius: Picasso
Darren Criss - The Assassination of Gianni Versace: American Crime Story
Benedict Cumberbatch - Patrick Melrose
Jeff Daniels - Looming Tower
John Legend - Jesus Christ Superstar: Live in Concert
Jesse Plemons - U.S.S. Callister (Black Mirror)
Best lead actor in a comedy series
Anthony Anderson - black-ish
Ted Danson - The Good Place
Larry David - Curb Your Enthusiasm
Donald Glover - Atlanta
Bill Hader - Barry
William H Macy - Shameless
Best lead actress in a comedy series
Pamela Adlon - Better Things
Allison Janney - Mom
Issa Rae - Insecure
Tracee Ellis Ross - black-ish
Lily Tomlin - Grace and Frankie
The Crown received 13 nominations
Best drama series
Game of Thrones
The Handmaid's Tale
This Is Us
Best comedy series
Curb Your Enthusiasm
The Marvelous Mrs. Maisel
Unbreakable Kimmy Schmidt
Best limited series
The Assassination of Gianni Versace: American Crime Story
Best TV movie
USS Callister (Black Mirror)
Comedy show Saturday Night Live's Michael Che and Colin Jost are set to host this years awards, on 17 September.